Anaphylactic shock is a life-threatening medical emergency from an allergic reaction that requires immediate treatment. Rapid-onset respiratory compromise, skin/mucosal involvement, and hypotensive end-organ dysfunction are all characteristic presentations (Brasted & Ruppel, 2016). The body’s response to the allergen is to release inflammatory mediators at a local site, but ultimately, the response is systemic, which leads to an overwhelming cascade that affects the homeostasis of the body. Due to an increase in vascular permeability, fluid shift from the intravascular to extravascular space can occur within minutes, resulting in edema, respiratory arrest, and circulatory collapse (Brasted & Ruppel, 2016). The effect leads to vasodilation and consequently, intravascular volume depletion resulting in systemic hypotension; the hypoperfusion affects every end organ.