I am taking a molecular biochemistry course in the department of chemistry, and professor requires us to write an NIH grant proposal as the final project of the semester. I have chosen a topic for you, you then will need to put forward 2-3 specific aims based on this chosen topic in order to write the proposal. Below is my chosen topic, which has been submitted to and approved by my professor.
Topic: Because natively unstructured proteins (or natively disordered proteins) can be easily degraded in the cell via ubiquitination or other pathways when they are no longer needed, it has been argued that there could be a benefit to being unfolded if very tight regulation of the protein function is required. To support this argument, it has been noted that many natively unfolded proteins have been found operating in signaling and transcriptional regulation pathways, where rapid switching of the signal is required. But there is little evidence for this idea.
The requirements of this project are as follows, I have already uploaded a sample NIH-style grant proposal as well as a very detail instruction on how to write this proposal, you will have to read them carefully before starting to write the proposal. You only need to write 4 parts in this proposal, those are: specific aims, significance/background, innovation, approach. In addition, when you cite other research papers as the references, please don’t forget to use superscript in the proposal and you have to give the reference list at the end of the proposal. You should use the papers published in ACS Publications (https://pubs.acs.org/)

Project: 30% of your grade is reserved for an original proposal. This includes a 5-page written document in the form of an NIH-style grant that will be reviewed by your peers. Your proposal should involve a novel idea to determine an unsolved problem in biochemistry (focus on structure-function relationship).Grading will be based on the originality of the idea, quality of written proposal, and evaluation from your peer review panel.

Structure of the Proposal (a detailed instruction can be found in the uploaded file, this structure is just a very brief instruction provided by our professor):
1. Specific Aims (1 page): The purpose of the specific aims is to describe concisely and realistically the goals of the proposed research and summarize the expected outcome(s), including the impact of the proposed research will exert on the research fields involved

2. Significance and background (~1.5 pages): The Significance section should explain the importance of the problem or describe the critical barrier to progress in the field that is being addressed. Explain how the proposed research project will improve scientific knowledge, technical capability, and/or clinical practice in one or more broad fields. Describe how the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field will be changed if the proposed aims are achieved. It should cover the state of existing knowledge, including literature citations and highlights of relevant data.

3. Innovation (~0.5 page): Explain how the application challenges and seeks to shift current research or clinical practice paradigms. Describe any novel theoretical concepts, approaches or methodologies, instrumentation or interventions to be developed or used, and any advantage over existing methodologies, instrumentation, or interventions. Explain any refinements, improvements, or new applications of theoretical concepts, approaches or methodologies, instrumentation, or interventions.

4. Approach: (~2 pages): The purpose of the approach section is to describe how the research will be carried out. This section is crucial to how favorably an application is reviewed.

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